Introduction

Targeted intrathecal drug infusion to treat moderate to severe chronic pain has become a standard part of treatment algorithms when more conservative options fail. This therapy is well established in literature, has shown efficacy, and is an important tool for the treatment of both cancer and noncancer pain.

Methods

The Polyanalgesic Consensus Conference is a meeting of experienced implanting physicians who strive to improve care in those receiving implantable devices. By employing data generated through an extensive literature search combined with clinical experience, this work group formulates recommendations regarding awareness, education, and mitigation of the morbidity and mortality associated with intrathecal therapy to establish the best practices for targeted intrathecal drug delivery systems.

Results

Best practices for improved patient care and outcomes with targeted intrathecal infusion are recommended to minimize the risk of morbidity and mortality. Areas of focus include: respiratory depression, infection, granuloma, device-related complications, endocrinopathies, and human error. Specific guidance is given with each of these issues and the general use of the therapy.

Conclusion